Search results for "Energy coupling"
showing 3 items of 3 documents
Metabolic Engineering of Bacterial Respiration: High vs. Low P/O and the Case of Zymomonas mobilis
2019
Respiratory chain plays a pivotal role in the energy and redox balance of aerobic bacteria. By engineering respiration, it is possible to alter the efficiency of energy generation and intracellular redox state, and thus affect the key bioprocess parameters: cell yield, productivity and stress resistance. Here we summarize the current metabolic engineering and synthetic biology approaches to bacterial respiratory metabolism, with a special focus on the respiratory chain of the ethanologenic bacterium Zymomonas mobilis. Electron transport in Z. mobilis can serve as a model system of bacterial respiration with low oxidative phosphorylation efficiency. Its application for redox balancing and re…
Seawater Desalination for Freshwater Production
2009
In the last decades more and more countries have experienced water scarcity problems, thus pointing at alternative non-conventional sources of fresh water. Seawater desalination has proven to be a reliable and economically sustainable water resource since the second half of the 20th Century. A number of well proven technologies already exist, with advantages and disadvantages making each of them more suitable in specific sites. Moreover, quite recently, coupling the use of renewable energy to the production of fresh water from seawater results in novel technologies, able to minimise the environmental impact that desalination processes can create due to their intense energy consumptions.
Cherimolin-1, New Selective Inhibitor of the First Energy-Coupling Site of the NADH:Ubiquinone Oxidoreductase (Complex I)
1997
The mechanism linking electron transport to proton translocation in the NADH:ubiquinone oxidoreductase (complex I of the mitochondrial respiratory chain) is still unclear. Inhibitors acting at different sites of the enzyme are powerful tools to clarify this mechanism. Up to now, a unique inhibitor, the Annonaceous acetogenin rolliniastatin-2, selectively blocks the most internal proton-translocation site. This study introduces cherimolin-1, a new acetogenin that inhibits the complex I with this special mode of action, which is more easily available from the plant material. Moreover, the mode of action of this scarce type of complex I inhibitor is further characterized.